・COX-2またはNSAIDs+アセトアミノフェン±弱オピオイド 1) Ljungqvist O, et al. Enhanced recovery after surgery: A review. JAMA Surg 2017; 152: 292─8. 2) Halabi WJ, et al. Epidural analgesia in laparo-scopic colorectal surgery: A nationwide analy-sis of use and outcomes. JAMA Surg 2014; 149: 130─6. 3) Guay J, et al. Epidural local anesthetics versus opioid-based analgesic regimens for postoper-ative gastrointestinal paralysis, vomiting, and pain after abdominal surgery: A Cochrane re-view. Anesth Analg 2016; 123: 1591─602. 4) Halabi WJ, et al. A nationwide analysis of the use and outcomes of epidural analgesia in open colorectal surgery. J Gastrointest Surg 2013; 17: 1130─7. 5) Feltracco P, et al. Perioperative benefit and outcome of thoracic epidural in esophageal surgery: A clinical review. Dis Esophagus 2018; 31: 1─14. 6) Panaretou V, et al. Postoperative pulmonary function after open abdominal aortic aneu-rysm repair in patients with chronic obstruc-tive pulmonary disease: Epidural versus intra-venous analgesia. Ann Vasc Surg 2012; 26: 149─55. 7) Joshi GP, et al. Evidence-based postoperative pain management after laparoscopic colorec-tal surgery. Colorectal Dis 2013; 15: 146─55. 文 献 COX:シクロオキシゲナーゼ、NSAIDs:非ステロイド性抗炎症薬、VAS:視覚アナログスケール(Joshi GP, et al. Evidence-based postoperative pain management after laparoscopic colorectal surgery. Colorectal Dis 2013; 15: 146─55より改変引用)108表2 腹腔鏡下大腸手術後の疼痛管理についての推奨手術終了前・デキサメタゾン4─8 mg・COX-2阻害薬、NSAIDs、アセトアミノフェンの静脈内投与・手術終了時の、創部への長時間作用型局所麻酔薬の浸潤麻酔・静脈内リドカインボーラス投与と持続投与手術終了後VASが50以上・COX-2阻害薬またはNSAIDs+アセトアミノフェン+静脈内オピオイドPCA・無効な場合、静脈内リドカイン投与VASが50以下いっそう高まっていますね。(小野 大輔、賀来 隆治)
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